منابع مشابه
Biomarkers in NHL
Patients with non-Hodgkin's lymphoma (NHL) are in need of better predictive and prognostic markers; this to be able to more accurately inform them in the clinical setting about their likely future and to better inform clinicians and clinician-researchers about treatment decisions. One of the major impediments to the development of such markers in NHL has been the relative lack of access to well...
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comorbidities, many patients eventually relapse or do not qualify for standard therapies 1,2. Additional treatment options that improve tolerability while maximizing efficacy are therefore needed in those settings. Bendamustine hydrochloride is a bifunctional alkylating agent with clinical activity across a number of cancers, including breast cancer, small-cell lung cancer, multiple myeloma, cl...
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Non-Hodgkin Lymphoma (NHL) is a heterogenous disease consisting of at least 40 different entities that are defined mainly by their clinical and histopathological presentation, their underlying genetic abnormalities but also their presumed cell of origin [1]. The latter can be of Bor Tcell type and derived from different stages of the differentiation process. B-cells are predisposed to DNA alter...
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Lymphomas are classified as Hodgkin’s and Non-Hodgkin’s lymphomas (HL NHL) NHL being further sub-divided into B, T and Null cell categories on the basis of WHO classification. With a few exceptions worldwide, B-NHL are more common, accounting approximately 80-85% of all cases of NHL compared to T-NHL, which accounts for about 10-15% of all NHL cases. The incidence of NHL has shown a steady incr...
متن کاملExploring Potential Germline-Associated Roles of the TRIM-NHL Protein NHL-2 Through RNAi Screening
TRIM-NHL proteins are highly conserved regulators of developmental pathways in vertebrates and invertebrates. The TRIM-NHL family member NHL-2 in Caenorhabditis elegans functions as a miRNA cofactor to regulate developmental timing. Similar regulatory roles have been reported in other model systems, with the mammalian ortholog in mice, TRIM32, contributing to muscle and neuronal cell proliferat...
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ژورنال
عنوان ژورنال: Info Onkologie
سال: 2012
ISSN: 1613-3633
DOI: 10.1007/s15004-012-0297-x